Hydrocortisone Phosphoric Acid

SCHEMBL8190634

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COP(=O)(O)O.O=P(O)(O)O.[NaH].[NaH]

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	8/20	0.66

▸	HIF1A	Q16665	10/20	0.66

▸	CHRM1	P11229	2/20	0.66

▸	CHRM4	P08173	1/20	0.66

▸	CHRM5	P08912	1/20	0.66

▸	CHRM3	P20309	1/20	0.66

▸	HRH1	P35367	1/20	0.66

▸	PIN1	Q13526	1/20	0.66

▸	CHRM2	P08172	1/20	0.66

▸	CYP3A4	P08684	8/20	0.60

▸	HSD17B10	Q99714	5/20	0.60

▸	NFKB1	P19838	4/20	0.60

▸	PGR	P06401	4/20	0.60

▸	TSHR	P16473	2/20	0.60

▸	AR	P10275	2/20	0.60

▸	KMT2A	Q03164	2/20	0.60

▸	NR3C2	P08235	2/20	0.60

▸	PMP22	Q01453	2/20	0.60

▸	MEN1	O00255	1/20	0.60

▸	CYP2D6	P10635	1/20	0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Dexamethasone SCHEMBL322760	0.92	HIF1A (0.69)	HIF1ANR3C1CYP3A4HSD17B10NFKB1
Betamethasone SCHEMBL28086533	0.90	HIF1A (0.66)	HIF1ANR3C1CYP3A4HSD17B10NFKB1
Triamcinolone SCHEMBL593313	0.87	HIF1A (0.68)	HIF1ANR3C1CYP3A4HSD17B10NFKB1
Prednisolone Phosphoric Acid SCHEMBL1930858	0.86	CYP3A4 (0.69)	HIF1ANR3C1CHRM1CHRM4CHRM5
Prednisolone Phosphoric Acid SCHEMBL7998176	0.86	CYP3A4 (0.71)	HIF1ANR3C1CHRM1CHRM4CHRM5
Hydrocortisone SCHEMBL8190636	0.85	NR3C1 (0.57)	HIF1ANR3C1CYP3A4HSD17B10NFKB1
Dexamethasone SCHEMBL4586353	0.84	HIF1A (0.56)	HIF1ANR3C1CYP3A4HSD17B10NFKB1
Betamethasone SCHEMBL7070539	0.83	NR3C1 (0.73)	HIF1ANR3C1CYP3A4HSD17B10NFKB1
Dexamethasone SCHEMBL3309785	0.83	NR3C1 (0.73)	HIF1ANR3C1CYP3A4HSD17B10NFKB1
Tixocortol Pivalate SCHEMBL4455114	0.82	HIF1A (0.60)	HIF1ANR3C1CYP3A4HSD17B10NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1008365-A1	DEVICE FOR IONTOPHORESIS	Kowa Co., Ltd. (JP)	2000-06-14	—	—	EP	disclosed