Hydrocortisone

SCHEMBL8190636

C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OP(=O)([O-])[O-])C(=O)CO.C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OP(=O)([O-])[O-])C(=O)CO.C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OP(=O)([O-])[O-])C(=O)CO.C[C@]12CCC(=O)C=C1CCC1C2[C@@H](O)C[C@@]2(C)C1CC[C@]2(O)C(=O)CO.O=P([O-])([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	11/20	0.57

▸	CYP3A4	P08684	7/20	0.57

▸	HIF1A	Q16665	5/20	0.57

▸	HSD17B10	Q99714	4/20	0.57

▸	PGR	P06401	4/20	0.57

▸	KMT2A	Q03164	3/20	0.57

▸	NFKB1	P19838	3/20	0.57

▸	CYP2C19	P33261	2/20	0.57

▸	MAPT	P10636	2/20	0.57

▸	NR3C2	P08235	2/20	0.57

▸	SHBG	P04278	1/20	0.57

▸	SERPINA6	P08185	1/20	0.57

▸	SMN1; SMN2	Q16637	1/20	0.57

▸	MEN1	O00255	2/20	0.56

▸	USP2	O75604	1/20	0.56

▸	MMP1	P03956	6/20	0.55

▸	TSHR	P16473	2/20	0.53

▸	AR	P10275	2/20	0.53

▸	CYP2D6	P10635	1/20	0.53

▸	APEX1	P27695	1/20	0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Dexamethasone SCHEMBL322760	0.89	HIF1A (0.69)	NR3C1CYP3A4HIF1AHSD17B10PGR
Triamcinolone SCHEMBL593313	0.86	HIF1A (0.68)	NR3C1CYP3A4HIF1AHSD17B10PGR
Betamethasone SCHEMBL28086533	0.85	HIF1A (0.66)	NR3C1CYP3A4HIF1AHSD17B10PGR
Hydrocortisone Phosphoric Acid SCHEMBL8190634	0.85	HIF1A (0.66)	NR3C1CYP3A4HIF1AHSD17B10PGR
SCHEMBL1048586	0.84	NR3C1 (0.75)	NR3C1CYP3A4HIF1AHSD17B10PGR
SCHEMBL472227	0.84	NR3C1 (0.75)	NR3C1CYP3A4HIF1AHSD17B10PGR
SCHEMBL337332	0.84	NR3C1 (0.75)	NR3C1CYP3A4HIF1AHSD17B10PGR
Betamethasone Valerate SCHEMBL3670653	0.82	NR3C1 (0.70)	NR3C1CYP3A4HIF1APGRKMT2A
Dexamethasone SCHEMBL4586353	0.81	HIF1A (0.56)	NR3C1CYP3A4HIF1AHSD17B10PGR
Prednisolone Phosphoric Acid SCHEMBL7998176	0.80	CYP3A4 (0.71)	NR3C1CYP3A4HIF1AHSD17B10PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1008365-A1	DEVICE FOR IONTOPHORESIS	Kowa Co., Ltd. (JP)	2000-06-14	—	—	EP	disclosed