SCHEMBL8190834

SCHEMBL8190834

CCOC(=O)Nc1cc(N(C(=O)OCC)S(C)(=O)=O)c(C#N)cc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 1/20 0.41
AR P10275 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
ALDH1A1 P00352 6/20 0.36
GAA P10253 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KCNQ2 O43526 2/20 0.35
KCNQ4 P56696 2/20 0.35
KCNQ3 O43525 1/20 0.35
KCNQ5 Q9NR82 1/20 0.35
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
GPR35 Q9HC97 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8333678 0.80 ALDH1A1 (0.50) NLRP3ARCYP1A2CYP2C9CYP2C19
SCHEMBL5847244 0.79 NLRP3 (0.49) NLRP3ARCYP1A2CYP2C9CYP2C19
SCHEMBL6662088 0.77 NLRP3 (0.44) NLRP3ARCYP1A2CYP2C9CYP2C19
SCHEMBL404508 0.76 NLRP3 (0.51) NLRP3ARCYP1A2CYP2C9CYP2C19
SCHEMBL6663679 0.76 CYP1A2 (0.39) CYP1A2CYP2C9CYP2C19SMN1; SMN2ALDH1A1
SCHEMBL406273 0.74 NLRP3 (0.49) NLRP3ARCYP1A2CYP2C9CYP2C19
SCHEMBL24825600 0.71 SMN1; SMN2 (0.52) NLRP3CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL405701 0.71 NLRP3 (0.49) NLRP3CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL462816 0.70 AR (0.47) NLRP3ARCYP1A2CYP2C9CYP2C19
SCHEMBL6593319 0.70 GAA (0.45) NLRP3ARCYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6110870-A SELECTIVE HERBICIDE FOR KILLING WEEDS BUT NOT OF A WHEAT, CORN OR SOYBEAN CROP, COMPOUNDS SUCH AS 1-(4-CYANO-2,5-DIFLUORO-PHENYL)-3,6-DIHYDRO-2,6-DIOXO-3-ETHYL-4 -TRIFLUOROMETHYL-1(2H)-PYRIMIDINE BAYER AKTIENGESELLSCHAFT (DE) 2000-08-29 US disclosed
EP-0648749-B1 N-cyanoaryl nitrogencontaining heterocycles BAYER AG (DE) 1997-12-10 EP disclosed
US-5681794-A HERBICIDE BAYER AKTIENGESELLSCHAFT (DE) 1997-10-28 US disclosed
US-5593945-A HERBICIDES AND CHEMICAL INTERMEDIATES BAYER AKTIENGESELLSCHAFT (DE) 1997-01-14 US disclosed
EP-0648749-A2 N-cynanoaryl nitrogencontaining heterocycles BAYER AG (DE) 1995-04-19 EP disclosed