Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14174367 | 0.86 | HSD17B1 (0.33) | ALOX15ALDH1A1EPHX2KMT2AL3MBTL1 | |
| SCHEMBL14463118 | 0.75 | TSHR (0.32) | TSHR | |
| SCHEMBL3711207 | 0.73 | HSD17B1 (0.36) | ALOX15ALDH1A1CYP1A2EPHX2KMT2A | |
| Beta-Pinene SCHEMBL1871597 | 0.72 | ABCB1 (0.39) | ALOX15ALDH1A1USP2TDP1CYP1A2 | |
| SCHEMBL14515015 | 0.70 | HSD17B1 (0.32) | ALOX15EPHX2KMT2AL3MBTL1TSHR | |
| SCHEMBL14462522 | 0.70 | HSD17B1 (0.32) | ALOX15EPHX2KMT2AL3MBTL1TSHR | |
| SCHEMBL14421889 | 0.69 | HSD17B1 (0.32) | ALOX15EPHX2KMT2AL3MBTL1 | |
| SCHEMBL14174366 | 0.68 | HSD17B1 (0.31) | — | |
| SCHEMBL10924881 | 0.68 | PTGDR (0.38) | ALDH1A1TDP1 | |
| SCHEMBL31033436 | 0.68 | KCNH2 (0.50) | TDP1KMT2ACYP4F2CYP4A11TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071935-A | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors | PFIZER INC. (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0907649-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049700-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |