Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14174367 | 0.87 | HSD17B1 (0.33) | HSD17B1KMT2AALOX15L3MBTL1TSHR | |
| SCHEMBL9416064 | 0.85 | BRD4 (0.36) | HSD17B10GAAALDH1A1 | |
| SCHEMBL14515015 | 0.82 | HSD17B1 (0.32) | HSD17B1KMT2AALOX15L3MBTL1TSHR | |
| SCHEMBL14462522 | 0.82 | HSD17B1 (0.32) | HSD17B1KMT2AALOX15L3MBTL1TSHR | |
| SCHEMBL14421889 | 0.81 | HSD17B1 (0.32) | HSD17B1KMT2AALOX15L3MBTL1EPHX2 | |
| SCHEMBL14174366 | 0.80 | HSD17B1 (0.31) | HSD17B1 | |
| SCHEMBL14186834 | 0.76 | TSHR (0.34) | TSHR | |
| SCHEMBL4642556 | 0.72 | MGAM (0.36) | HSD17B1KMT2ATSHRHSD17B10POLB | |
| SCHEMBL3705538 | 0.71 | MGAM (0.39) | KMT2AALOX15L3MBTL1TSHRHSD17B10 | |
| SCHEMBL3705541 | 0.71 | MGAM (0.39) | KMT2AALOX15L3MBTL1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609674-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120122890-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
| US-7390926-B2 | Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3 | ZACH SYSTEM (IT) | 2008-06-24 | — | — | US | disclosed |
| US-20070225516-A1 | Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3 | PPG-SIPSY (FR) | 2007-09-27 | — | — | US | disclosed |
| US-20070225516-A1 | Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3 | PPG-SIPSY (FR) | 2007-09-27 | — | — | US | disclosed |
| EP-1808427-A2 | Novel processes for the preparation of bicyclic aminoalcohols | SHIONOGI & CO., LTD. (JP) | 2007-07-18 | — | — | EP | disclosed |
| US-7214832-B2 | Processes for the preparation of bicyclic aminoalcohols | SHIONOGI & CO., LTD. (JP) | 2007-05-08 | — | — | US | disclosed |
| US-7214832-B2 | Processes for the preparation of bicyclic aminoalcohols | SHIONOGI & CO., LTD. (JP) | 2007-05-08 | — | — | US | disclosed |
| US-7214832-B2 | Processes for the preparation of bicyclic aminoalcohols | SHIONOGI & CO., LTD. (JP) | 2007-05-08 | — | — | US | disclosed |
| US-20040171882-A1 | Novel processes for the preparation of bicyclic aminoalcohols | HONMA TSUNETOSHI (JP) | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171882-A1 | Novel processes for the preparation of bicyclic aminoalcohols | DOHH, OXER1, XDH | HSD17B1 631/4885KMT2A 1324/4885ALOX15 170/4885 |
| US-20070225516-A1 | Process for the diastereoselective alkylation of an ether oxime of the compound nopinone and novel intermediates for the synthesis of diastereospecific 2-amino-nopinone derivatives substituted on carbon 3 | NOP2, NOP10, NOP56 | HSD17B1 211/4885KMT2A 2644/4885ALOX15 500/4885 |
| US-20120122890-A1 | Potassium Channel Modulators | KCNQ1, KCNQ2, KCNQ3 | HSD17B1 3189/4885KMT2A 432/4885ALOX15 4354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.