Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | DRD3 | P35462 | 7/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8186159 | 0.99 | GRIN2B (0.52) | GRIN2BDRD2DRD3DRD4OPRM1 | |
| Hydrochloric Acid SCHEMBL8188456 | 0.88 | GRIN2B (0.44) | GRIN2BDRD2DRD3OPRM1SIGMAR1 | |
| SCHEMBL9776938 | 0.87 | GRIN2B (0.54) | GRIN2BDRD2DRD3DRD4 | |
| SCHEMBL9776768 | 0.85 | DRD2 (0.54) | GRIN2BDRD2DRD3DRD4HTR1A | |
| SCHEMBL9716394 | 0.80 | HRH3 (0.41) | GRIN2BDRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL8191977 | 0.79 | GRIN2B (0.58) | GRIN2BDRD2DRD3DRD4 | |
| SCHEMBL3466286 | 0.78 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL3466317 | 0.78 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL29507795 | 0.78 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL3466289 | 0.78 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117898-A | Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase | ASTRA AKTIEBOLAG (SE) | 2000-09-12 | — | — | US | disclosed |
| EP-0759027-B1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | ASTRA AB (SE) | 1999-08-04 | — | — | EP | disclosed |
| US-5807886-A | Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| US-5053430-A | For treating schizophrenia | BOEHRINGER INGELHEIM KG (DE) | 1991-10-01 | — | — | US | disclosed |
| EP-0361300-A1 | Use of 2,7 diamino-1,2,3,4-tetrahydronaphthalenes as drugs, 2,7 diamino-1,2,3,4-tetrahydronaphthalenes as well as processes for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1990-04-04 | — | — | EP | disclosed |