Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8188456 | 0.90 | GRIN2B (0.44) | DRD2DRD3GRIN2BNAAASIGMAR1 | |
| SCHEMBL5208142 | 0.87 | HRH4 (0.44) | HRH3HRH4MAPTDRD2DRD3 | |
| SCHEMBL9769473 | 0.85 | SIGMAR1 (0.43) | DRD2DRD3DRD4GRIN2BSIGMAR1 | |
| SCHEMBL8191908 | 0.80 | GRIN2B (0.53) | DRD2DRD3DRD4GRIN2BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8186159 | 0.79 | GRIN2B (0.52) | DRD2DRD3DRD4GRIN2BSIGMAR1 | |
| Aniline SCHEMBL27296362 | 0.79 | DRD3 (0.46) | HRH3MAPTDRD2DRD3DRD4 | |
| SCHEMBL3466440 | 0.78 | DRD2 (0.43) | MAPTDRD2DRD3DRD4 | |
| SCHEMBL3466437 | 0.78 | DRD2 (0.43) | MAPTDRD2DRD3DRD4 | |
| SCHEMBL3467135 | 0.78 | DRD2 (0.43) | MAPTDRD2DRD3DRD4 | |
| SCHEMBL29507943 | 0.78 | DRD2 (0.46) | MAPTDRD2DRD3DRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130334-A | INDANE SULFONAMIDE ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5006561-A | Indane sulfonamide anti-arrhythmic agents and use | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0286277-B1 | ANTIARRYTHMIC AGENTS | Pfizer Limited (GB) | 1990-06-20 | — | — | EP | disclosed |
| CN-1038449-A | Antiarrhythmics | PFIZER LTD (GB) | 1990-01-03 | — | — | CN | disclosed |
| US-4829071-A | Quinolyl substituted indane sulfonamides and their use as anti-arrhythmic agents | PFIZER INC. (US) | 1989-05-09 | — | — | US | disclosed |
| EP-0286277-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-10-12 | — | — | EP | disclosed |
| EP-0286278-A1 | Indanamine derivatives useful as antiarrhythmic agents | Pfizer Limited (GB) | 1988-10-12 | — | — | EP | disclosed |