Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214241 | 0.83 | KDM4E (0.70) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL31120339 | 0.82 | ADORA1 (0.74) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL8191930 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL8192643 | 0.76 | ADK (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2TDP1 | |
| SCHEMBL6255131 | 0.71 | ADORA1 (0.76) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL8139423 | 0.70 | ADORA1 (0.62) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL31120351 | 0.70 | ADORA1 (0.83) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL8144986 | 0.69 | ADORA1 (0.60) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL13914338 | 0.69 | KDM4E (0.56) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL31120343 | 0.69 | ADORA1 (0.78) | KDM4EALDH1A1LMNAHPGDRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |