Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15117089 | 0.77 | RAB9A (0.55) | MAPTRAB9AHRH3MAPK14LCK | |
| SCHEMBL1443072 | 0.75 | MAPT (0.46) | MAPTRAB9AMAPK14LCKMAP2K1 | |
| SCHEMBL4556755 | 0.74 | CNR2 (0.39) | CNR2HRH3ATR | |
| SCHEMBL12460537 | 0.74 | NPC1 (0.45) | RAB9AHRH3 | |
| SCHEMBL16750254 | 0.72 | CNR2 (0.51) | CNR2MAPTHDAC6CNR1 | |
| SCHEMBL1435967 | 0.71 | NPC1 (0.65) | MAPTRAB9A | |
| SCHEMBL12460253 | 0.71 | KDM4E (0.44) | RAB9A | |
| SCHEMBL14804393 | 0.71 | NPC1 (0.56) | MAPTRAB9A | |
| SCHEMBL4849597 | 0.71 | PDE10A (0.51) | CNR2MAPTHRH3HDAC6CNR1 | |
| SCHEMBL23850484 | 0.70 | RAB9A (0.65) | MAPTRAB9AHRH3MAPK14LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |