Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 7/20 | 0.35 |
| ▸ | CTSA | P10619 | 5/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185553 | 0.92 | MAPK8 (0.34) | BRS3CTSAMAPK8MAPK10SLC6A9 | |
| SCHEMBL8199840 | 0.85 | FNTA (0.39) | — | |
| SCHEMBL8199591 | 0.85 | CTSA (0.39) | BRS3CTSA | |
| SCHEMBL8197252 | 0.85 | ALDH1A1 (0.32) | CTSASLC6A9 | |
| SCHEMBL7561796 | 0.83 | CTSA (0.33) | CTSAKDM5AKDM4CKDM5BSLC6A9 | |
| SCHEMBL7610663 | 0.81 | BRS3 (0.35) | BRS3CTSAKDM5AKDM4CKDM5B | |
| SCHEMBL8194512 | 0.79 | PTGS1 (0.37) | BRS3CTSASLC6A4SLC6A3 | |
| SCHEMBL8194981 | 0.78 | CTSA (0.35) | BRS3CTSAKDM5AKDM4CKDM5B | |
| SCHEMBL8193533 | 0.77 | CTSA (0.35) | BRS3CTSAKDM5AKDM4CKDM5B | |
| SCHEMBL7564011 | 0.76 | CYP11B1 (0.35) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025088-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999020611-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |