Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.34 |
| ▸ | CTSL | P07711 | 5/20 | 0.33 |
| ▸ | CTSB | P07858 | 5/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | CTSH | P09668 | 4/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193171 | 0.98 | CTSK (0.32) | CTSKCTSLCTSBREN | |
| SCHEMBL8192178 | 0.94 | — | — | |
| SCHEMBL8192192 | 0.90 | — | — | |
| SCHEMBL10433960 | 0.90 | CTSK (0.33) | CTSKCTSLCTSBCTSHCYP1A2 | |
| SCHEMBL15732817 | 0.87 | CTSK (0.31) | CTSKCYP1A2 | |
| SCHEMBL13183864 | 0.76 | CYP1A2 (0.39) | CTSKCTSLCTSBCTSHCYP1A2 | |
| SCHEMBL3343320 | 0.74 | CTSK (0.33) | CTSKCTSLCTSBCTSH | |
| SCHEMBL14537236 | 0.74 | CTSK (0.45) | CTSKCTSLCTSBCTSHCYP1A2 | |
| SCHEMBL7391857 | 0.74 | REN (0.35) | CTSKCTSLCTSBRENBCHE | |
| SCHEMBL28410450 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110903-A | INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE AT THE AMP SITE; ADMINISTERING TO TREAT DIABETES AND INHIBIT GLUCONEOGENESIS; 5-FLUORO-7-BROMO-1-ISOBUTYL-2-(2-PHOSPHONO-5-FURANYL) BENZIMIDAZOLE, FOR EXAMPLE | SANKYO COMPANY LTD. (JP) | 2000-08-29 | — | — | US | disclosed |