Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclofenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 7/20 | 0.77 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | GMNN | O75496 | 1/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclofenamic Acid SCHEMBL8531474 | 1.00 | PTGS2 (0.77) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL8465128 | 1.00 | PTGS2 (0.77) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL436190 | 0.92 | PTGS2 (0.83) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL18171844 | 0.92 | PTGS2 (0.90) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL8193707 | 0.92 | PTGS2 (0.83) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL30241166 | 0.88 | PTGS2 (1.00) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL1874563 | 0.88 | PTGS2 (1.00) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL3504 | 0.88 | PTGS2 (1.00) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL4400214 | 0.88 | PTGS2 (1.00) | PTGS2MEN1KMT2ALMNACYP1A2 | |
| Meclofenamic Acid SCHEMBL29460464 | 0.87 | PTGS2 (0.97) | PTGS2MEN1KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11419938-B2 | Phenylephrine-containing liquid formulations | GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS LLC (US) | 2022-08-23 | — | — | US | claimed |
| US-20190209688-A1 | Phenylephrine-Containing Liquid Formulations | WYETH LLC (US) | 2019-07-11 | — | — | US | claimed |
| US-20170333561-A1 | Phenylephrine-Containing Liquid Formulations | WYETH LLC (US) | 2017-11-23 | — | — | US | claimed |
| US-20150150976-A1 | PHENYLEPHRINE-CONTAINING LIQUID FORMULATIONS | HALEON US HOLDINGS LLC | 2015-06-04 | — | — | US | claimed |
| US-8940796-B2 | Phenylephrine liquid formulations | WYETH LLC (US) | 2015-01-27 | — | — | US | claimed |
| EP-2351554-A1 | Enhanced stability phenylephrine liquid compositions | Wyeth LLC (US) | 2011-08-03 | — | — | EP | claimed |
| EP-2316425-A1 | Liquid formulations comprising an active agent, glycerine and sorbitol | Wyeth LLC (US) | 2011-05-04 | — | — | EP | claimed |
| EP-2043619-A2 | CHEWABLE TABLET CONTAINING PHENYLEPHRINE | Wyeth (US) | 2009-04-08 | — | — | EP | claimed |
| EP-2040672-A2 | ENHANCED STABILITY PHENYLEPHRINE LIQUID COMPOSITIONS | Wyeth (US) | 2009-04-01 | — | — | EP | claimed |
| EP-1986606-A2 | PHENYLEPHRINE-CONTAINING LIQUID FORMULATIONS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-05 | — | — | EP | claimed |
| US-20080026055-A1 | Chewable tablet containing phenylephrine | WYETH (US) | 2008-01-31 | — | — | US | claimed |
| WO-2008013710-A2 | CHEWABLE TABLET CONTAINING PHENYLEPHRINE | WYETH (US) | 2008-01-31 | — | — | WO | claimed |
| US-20080014274-A1 | Enhanced stability phenylephrine liquid compositions | WYETH (US) | 2008-01-17 | — | — | US | claimed |
| WO-2008008364-A2 | ENHANCED STABILITY PHENYLEPHRINE LIQUID COMPOSITIONS | WYETH (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2007098128-A2 | PHENYLEPHRINE-CONTAINING LIQUID FORMULATIONS | WYETH (US) | 2007-08-30 | — | — | WO | claimed |
| US-20070197661-A1 | Phenylephrine liquid formulations | WYETH (US) | 2007-08-23 | — | — | US | claimed |
| US-20220047702-A1 | TARGETED MAGNETIC VEHICLES AND METHOD OF USING THE SAME | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2022-02-17 | — | — | US | disclosed |
| US-9295736-B2 | Polymer nanoparticles coated by magnetic metal oxide and uses thereof | BAR ILAN UNIVERSITY (IL) | 2016-03-29 | — | — | US | disclosed |
| WO-2009040811-A2 | POLYMER NANOPARTICLES COATED BY MAGNETIC METAL OXIDE AND USES THEREOF | BAR-ILAN UNIVERSITY (IL) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009040814-A1 | USE OF COPOLYMER 1 FOR TREATMENT OF MUSCULAR DYSTROPHY | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD (IL) | 2009-04-02 | — | — | WO | disclosed |