SCHEMBL819485

SCHEMBL819485

N#Cc1cc(C#N)c2ccccc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.56
CA2 P00918 4/20 0.56
NCOA3 Q9Y6Q9 1/20 0.47
CLK1 P49759 1/20 0.45
DYRK1A Q13627 1/20 0.45
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 2/20 0.44
XDH P47989 1/20 0.43
SLC22A12 Q96S37 1/20 0.43
TSHR P16473 1/20 0.41
ENPP3 O14638 1/20 0.39
CYP1B1 Q16678 2/20 0.39
CYP1A1 P04798 1/20 0.39
CYP1A2 P05177 1/20 0.39
GAA P10253 1/20 0.39
HTT P42858 1/20 0.39
IMPDH2 P12268 1/20 0.38
IMPDH1 P20839 1/20 0.38
KDM2B Q8NHM5 2/20 0.38
HIF1A Q16665 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29482237 1.00 CA1 (0.56) CA1CA2NCOA3CLK1DYRK1A
SCHEMBL4655972 0.86 CA1 (0.56) CA1CA2NCOA3CLK1DYRK1A
SCHEMBL818634 0.84 CA1 (0.44) CA1CA2NCOA3CLK1DYRK1A
SCHEMBL29420450 0.81 IMPDH2 (0.47) CA1CA2NCOA3ALDH1A1IMPDH2
SCHEMBL8852599 0.81 IMPDH2 (0.47) CA1CA2NCOA3ALDH1A1IMPDH2
SCHEMBL23087824 0.79 NCOA3 (0.47) CA1CA2NCOA3CLK1DYRK1A
SCHEMBL819504 0.79 CA1 (0.47) CA1CA2NCOA3IMPDH2IMPDH1
SCHEMBL29735114 0.79 NCOA3 (0.47) CA1CA2NCOA3CLK1DYRK1A
SCHEMBL7304752 0.79 CA1 (0.61) CA1CA2NCOA3CLK1DYRK1A
SCHEMBL31588629 0.78 NCOA3 (0.65) CA1CA2NCOA3CLK1DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2382241-B1 POLYMERS FUNCTIONALIZED WITH POLYCYANO COMPOUNDS BRIDGESTONE CORP (JP) 2016-11-23 EP claimed
US-8785566-B2 Polymers functionalized with polycyano compounds BRIDGESTONE CORPORATION (JP) 2014-07-22 US claimed
CN-114196204-B Prepreg, laminate, metal foil-clad laminate, printed wiring board, and multilayer printed wiring board 三菱瓦斯化学株式会社 2024-07-16 CN disclosed
CN-118251445-A Cyclic organosiloxane containing imide bond and polymerizable unsaturated bond and curable resin composition containing the same 信越化学工业株式会社 2024-06-25 CN disclosed
CN-118251457-A Thermosetting resin composition, prepreg and printed wiring board 三菱瓦斯化学株式会社 2024-06-25 CN disclosed
CN-118251458-A Curable composition, prepreg, resin sheet, metal foil-clad laminate, and printed wiring board 三菱瓦斯化学株式会社 2024-06-25 CN disclosed
CN-118234802-A Resin composition, prepreg, resin sheet, laminate, metal foil-clad laminate, and printed wiring board 三菱瓦斯化学株式会社 2024-06-21 CN disclosed
CN-117836359-A Prepreg, metal foil-clad laminate, and printed circuit board 三菱瓦斯化学株式会社 2024-04-05 CN disclosed
CN-117836370-A Curable composition, prepreg, resin sheet, metal foil-clad laminate, and printed wiring board 三菱瓦斯化学株式会社 2024-04-05 CN disclosed
CN-117836369-A Curable composition, prepreg, metal foil-clad laminate, and printed wiring board 三菱瓦斯化学株式会社 2024-04-05 CN disclosed
CN-117795016-A Resin composition, resin sheet, prepreg, metal foil-clad laminate, and printed wiring board 三菱瓦斯化学株式会社 2024-03-29 CN disclosed
EP-0908447-B1 PROCESS FOR THE PREPARATION OF CYANOARYLMETHYLAMINE SHOWA DENKO KK (JP) 2007-03-28 EP disclosed
CN-1100035-C Process for preparing cyanoarylmethylamine SHOWA DENKO KK (JP) 2003-01-29 CN disclosed
EP-0971984-A4 METHODS FOR INSERTING SILICON INTO PHTHALOCYANINES AND NAPHTHALOCYANINES UNIV CASE WESTERN RESERVE (US) 2002-03-06 EP disclosed
US-6114277-A Process for preparing cyano group-containing aromatic methylamines SHOWA DENKO K.K. (JP) 2000-09-05 US disclosed
EP-0971984-A1 METHODS FOR INSERTING SILICON INTO PHTHALOCYANINES AND NAPHTHALOCYANINES CASE WESTERN RESERVE UNIVERSITY (US) 2000-01-19 EP disclosed
CN-1216038-A Process for preparing cyanoarylmethylamine SHOWA DENKO KK (JP) 1999-05-05 CN disclosed
EP-0908447-A1 PROCESS FOR THE PREPARATION OF CYANOARYLMETHYLAMINE SHOWA DENKO KABUSHIKI KAISHA (JP) 1999-04-14 EP disclosed
WO-1998044052-A1 METHODS FOR INSERTING SILICON INTO PHTHALOCYANINES AND NAPHTHALOCYANINES CASE WESTERN RESERVE UNIVERSITY (US) 1998-10-08 WO disclosed
US-4756845-A Peroxide, cyanopyridine activator, cyanopyridinium salt LION CORPORATION (JP) 1988-07-12 US disclosed