Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxpheneridine SCHEMBL2110574 | 0.81 | OPRM1 (0.73) | OPRM1OPRD1OPRK1KDM4EALDH1A1 | |
| SCHEMBL157791 | 0.79 | SLC6A4 (0.54) | OPRM1KDM4E | |
| SCHEMBL8216333 | 0.78 | OPRM1 (0.67) | OPRM1OPRD1OPRK1KCNA3 | |
| SCHEMBL8188817 | 0.78 | OPRM1 (0.52) | OPRM1OPRD1OPRK1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL27797653 | 0.77 | SLC6A2 (0.55) | OPRM1KDM4EALDH1A1 | |
| SCHEMBL15776154 | 0.76 | AKR1C1 (0.53) | KDM4EALDH1A1 | |
| Propionic Acid SCHEMBL9328573 | 0.73 | GAA (0.71) | OPRM1GAAOPRD1KDM4EALDH1A1 | |
| SCHEMBL24726709 | 0.73 | OPRM1 (0.53) | OPRM1GAAOPRD1OPRK1KDM4E | |
| Acetic Acid SCHEMBL9325415 | 0.73 | GAA (0.75) | OPRM1GAAOPRD1KDM4EALDH1A1 | |
| SCHEMBL7305346 | 0.72 | OPRM1 (0.61) | OPRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743940-B1 | NEW COMPOUNDS WITH ANALGESIC AND LOCAL ANAESTHETIC EFFECT | ASTRA AB (SE) | 2000-05-03 | — | — | EP | disclosed |
| US-5968953-A | FOR SIDE EFFECT REDUCTION | ASTRA AB (SE) | 1999-10-19 | — | — | US | disclosed |
| US-5756520-A | N-SUBSTITUTED 4-PHENYL-4-CARBOXAMIDE-PIPERIDINE COMPOUNDS ARE ADMINISTERED EPIDURALLY OR INTRATHECALLY FOR CONTROLLING NERVE BLOCKADE IN HUMANS | ASTRA AB (SE) | 1998-05-26 | — | — | US | disclosed |
| EP-0743940-A1 | NEW COMPOUNDS WITH ANALGESIC AND LOCAL ANAESTHETIC EFFECT | Astra Aktiebolag (SE) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021821-A1 | NEW COMPOUNDS WITH ANALGESIC AND LOCAL ANAESTHETIC EFFECT | ASTRA AKTIEBOLAG (SE) | 1995-08-17 | — | — | WO | disclosed |