Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.67 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188731 | 0.83 | KCNA3 (0.58) | KCNA3OPRL1HTR1A | |
| SCHEMBL8216361 | 0.81 | KCNA3 (0.56) | KCNA3OPRL1HTR1A | |
| Phenoperidine SCHEMBL80415 | 0.81 | KCNA3 (0.83) | OPRM1KCNA3OPRD1OPRK1 | |
| Sameridine SCHEMBL419071 | 0.81 | OPRM1 (1.00) | OPRM1KCNA3OPRD1OPRK1 | |
| Phenoperidine SCHEMBL394330 | 0.80 | KCNA3 (0.81) | OPRM1KCNA3OPRD1OPRK1 | |
| Phenoperidine SCHEMBL1652634 | 0.79 | KCNA3 (0.80) | OPRM1KCNA3OPRD1OPRK1 | |
| SCHEMBL8195038 | 0.78 | OPRM1 (0.50) | OPRM1KCNA3OPRD1OPRK1 | |
| SCHEMBL8187800 | 0.76 | OPRM1 (0.65) | OPRM1KCNA3OPRD1OPRK1 | |
| SCHEMBL11716765 | 0.74 | OPRL1 (0.78) | OPRM1OPRL1OPRD1OPRK1 | |
| Phenoperidine SCHEMBL28832646 | 0.72 | KCNA3 (0.67) | OPRM1KCNA3OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067989-C | Novel compounds with analgesic and local anaesthetic effect | ASTRA AB (SE) | 2001-07-04 | — | — | CN | disclosed |
| EP-0743940-B1 | NEW COMPOUNDS WITH ANALGESIC AND LOCAL ANAESTHETIC EFFECT | ASTRA AB (SE) | 2000-05-03 | — | — | EP | disclosed |
| US-5968953-A | FOR SIDE EFFECT REDUCTION | ASTRA AB (SE) | 1999-10-19 | — | — | US | disclosed |
| US-5756520-A | N-SUBSTITUTED 4-PHENYL-4-CARBOXAMIDE-PIPERIDINE COMPOUNDS ARE ADMINISTERED EPIDURALLY OR INTRATHECALLY FOR CONTROLLING NERVE BLOCKADE IN HUMANS | ASTRA AB (SE) | 1998-05-26 | — | — | US | disclosed |
| CN-1140448-A | New compounds with analgesic and local anaesthetic effect | ASTRA AB (SE) | 1997-01-15 | — | — | CN | disclosed |
| EP-0743940-A1 | NEW COMPOUNDS WITH ANALGESIC AND LOCAL ANAESTHETIC EFFECT | Astra Aktiebolag (SE) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021821-A1 | NEW COMPOUNDS WITH ANALGESIC AND LOCAL ANAESTHETIC EFFECT | ASTRA AKTIEBOLAG (SE) | 1995-08-17 | — | — | WO | disclosed |