Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | TACR1 | P25103 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196579 | 1.00 | MAPT (0.62) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL17859729 | 0.85 | MAPT (0.58) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL1981757 | 0.85 | MAPT (0.68) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL8354794 | 0.84 | KDM4E (0.50) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL8358740 | 0.84 | KDM4E (0.50) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL27582874 | 0.84 | MEN1 (0.61) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL23723484 | 0.84 | MAPT (0.76) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL29472033 | 0.84 | MAPT (0.76) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL8360534 | 0.84 | ERAP2 (0.49) | MAPTKDM4EMEN1LMNAKMT2A | |
| SCHEMBL1401159 | 0.84 | KDM4E (0.71) | MAPTKDM4EMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000930-A2 | Tachykinin antagonists | WARNER-LAMBERT COMPANY (US) | 2000-05-17 | — | — | EP | disclosed |
| US-5981755-A | Tachykinin antagonists | WARNER-LAMBERT COMPANY (US) | 1999-11-09 | — | — | US | disclosed |
| US-5856354-A | RESPIRATORY SYSTEM DISORDERS, ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL DISORDERS, VISION DEFECTS, ANTIALLERGENS,PAIN, NERVOUS SYSTEM DISORDERS, HEADACHES | WARNER-LAMBERT COMPANY (US) | 1999-01-05 | — | — | US | disclosed |
| US-5716979-A | NONPEPTIDES, UNIQUE IN ALKYLATION/SUBSTITUTION PATTERN ALONG THEIR BACKBONE, USEFUL FOR TREATING DISORDERS SUCH AS RESPIRATORY, INFLAMMATORY, GASTROINTESTINAL, OPHTHALMIC, ALLERGIES, PAIN, VASCULAR, MIGRANE, ARTHRITIS AND BRAIN | WARNER-LAMBERT COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5594022-A | CARBAMATES | WARNER-LAMBERT COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0655055-A1 | TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004494-A1 | TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |