Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14819135 | 0.98 | ATM (0.67) | KMT2AATMKDM4EHTTPABPC1 | |
| SCHEMBL8662086 | 0.92 | ATM (0.60) | KMT2AATMKDM4EHTTPABPC1 | |
| SCHEMBL8662089 | 0.90 | ATM (0.58) | KMT2AATMKDM4EHTTPABPC1 | |
| SCHEMBL8968392 | 0.89 | KDM4E (0.58) | KMT2AATMKDM4EHTTPABPC1 | |
| Bromide SCHEMBL31501121 | 0.86 | ATM (0.68) | KMT2AATMKDM4EHTTALDH1A1 | |
| Bromide SCHEMBL3616347 | 0.81 | KDM4E (0.70) | KMT2AATMKDM4EHTTPABPC1 | |
| Bromide SCHEMBL1313220 | 0.81 | ATM (0.62) | KMT2AATMKDM4EHTTPABPC1 | |
| Bromide SCHEMBL11696712 | 0.81 | ATM (0.61) | KMT2AATMKDM4EHTTALDH1A1 | |
| Bromide SCHEMBL698678 | 0.81 | KDM4E (0.79) | KMT2AATMKDM4EHTTPABPC1 | |
| Hydrochloric Acid SCHEMBL8660681 | 0.80 | TDP1 (0.56) | KMT2AATMKDM4EHTTPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015907-A | PHOTOSTABLE IMAGING DYES FOR ACID-MEDIATED MEDIA, ALSO FOR PHOTOSENSITIZING ONIUM SALTS TO VISIBLE BLUE RADIATION | POLAROID CORPORATION (US) | 2000-01-18 | — | — | US | disclosed |
| US-6004719-A | ACID-GENERATING LAYER OR PHASE COMPRISING A MIXTURE OF A SUPERACID PRECURSOR, A SENSITIZING DYE AND A SECONDARY ACID GENERATOR, AND A COLOR-CHANGE LAYER OR PHASE COMPRISING AN IMAGE DYE. | POLAROID CORPORATION (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0951661-A4 | — | — | 1999-11-17 | — | — | EP | disclosed |
| EP-0951661-A1 | PROCESS AND COMPOSITION FOR GENERATING ACID | POLAROID CORPORATION (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0757629-B1 | IMAGING MEDIUM AND PROCESS | POLAROID CORP (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0681225-B1 | Electrostatic toner comprising phenacyl compounds | BASF AG (DE) | 1998-11-18 | — | — | EP | disclosed |
| WO-1998024000-A1 | PROCESS AND COMPOSITION FOR GENERATING ACID | POLAROID CORPORATION (US) | 1998-06-04 | — | — | WO | disclosed |
| US-5631118-A | MULTILAYER ELEMENT WITH ACID GENERATING LAYER, ACID PRECURSOR, SENSITIZING DYE, ACID GENERATOR AND COLOR CHANGING LAYER | POLAROID CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0757629-A1 | IMAGING MEDIUM AND PROCESS | POLAROID CORPORATION (US) | 1997-02-12 | — | — | EP | disclosed |
| US-5541032-A | CHARGE STABILIZERS WHICH ARE INSENSITIVE TO MOISTURE, HEAT RESISTANT AND PRODUCE CRISP, UNIFORM VISIBLE IMAGES OF HIGH COLOR INTENSITY | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0681225-A1 | Electrostatic toner comprising phenacyl compounds | BASF AKTIENGESELLSCHAFT (DE) | 1995-11-08 | — | — | EP | disclosed |
| WO-1995029068-A1 | IMAGING MEDIUM AND PROCESS | POLAROID CORPORATION (US) | 1995-11-02 | — | — | WO | disclosed |
| US-5441850-A | Exposing medium to actinic radiation in specified wavelength so sensitizing dye decomposes superacid precursor, heating to decompose secondary acid generator, mixing acid generating and color change layers to form image, providing base to restore | POLAROID CORPORATION (US) | 1995-08-15 | — | — | US | disclosed |
| US-RE29153-E | HERBICIDES, INSECTICIDES | MONSANTO COMPANY (US) | 1977-03-15 | — | — | US | disclosed |