Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841434 | 0.98 | ALDH1A1 (0.69) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| Iodide SCHEMBL20704647 | 0.96 | PABPC1 (0.70) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL5907533 | 0.96 | ALDH1A1 (0.72) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8660257 | 0.92 | KDM4E (0.64) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8660261 | 0.89 | ALDH1A1 (0.59) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8968159 | 0.88 | KDM4E (0.63) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| Bromide SCHEMBL31501128 | 0.86 | LMNA (0.74) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| Bromide SCHEMBL27941533 | 0.85 | KDM4E (0.79) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| Bromide SCHEMBL698678 | 0.85 | KDM4E (0.79) | KDM4ELMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL765905 | 0.83 | KDM4E (0.76) | KDM4ELMNAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816352-B2 | antiapoptosis agents such as 1-[2-Methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)-ethyl]-quinolinium bromide, used for cytoprotection or for side effect reduction of anticarcinogenic agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-19 | — | — | US | disclosed |
| US-20080280903-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-11-13 | — | — | US | disclosed |
| WO-2006099301-A2 | APOPTOSIS INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-09-21 | — | — | WO | disclosed |
| EP-0681225-B1 | Electrostatic toner comprising phenacyl compounds | BASF AG (DE) | 1998-11-18 | — | — | EP | disclosed |
| US-5541032-A | CHARGE STABILIZERS WHICH ARE INSENSITIVE TO MOISTURE, HEAT RESISTANT AND PRODUCE CRISP, UNIFORM VISIBLE IMAGES OF HIGH COLOR INTENSITY | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0681225-A1 | Electrostatic toner comprising phenacyl compounds | BASF AKTIENGESELLSCHAFT (DE) | 1995-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280903-A1 | Apoptosis Inhibitors | BAD, MCL1, AIFM1 | KDM4E 3580/4885LMNA 1596/4885ALDH1A1 2244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.