SCHEMBL8197818

SCHEMBL8197818

CSCC[C@H](NC(=O)c1ccc(COCC(c2ccc(F)cc2)c2cnc(C)[nH]2)cc1-c1ccc(F)cc1)C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 4/20 0.48
FNTB P49356 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8193375 0.89 FNTA (0.36) FNTAFNTB
SCHEMBL8193362 0.85 KMT2A (0.38) FNTAFNTB
SCHEMBL8194672 0.85 FNTA (0.47) FNTAFNTB
SCHEMBL8185757 0.84 FNTA (0.33) FNTAFNTB
SCHEMBL8185616 0.84 BRS3 (0.41)
SCHEMBL8185124 0.80 FNTA (0.42) FNTAFNTB
SCHEMBL8194556 0.80 FNTA (0.35) FNTAFNTB
SCHEMBL8197817 0.79 FNTA (0.44) FNTAFNTB
SCHEMBL7562579 0.78 FNTA (0.49) FNTAFNTB
SCHEMBL8199850 0.78 FNTA (0.40) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1025088-A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS AstraZeneca UK Limited (GB) 2000-08-09 EP disclosed
WO-1999020611-A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS ZENECA LIMITED (GB) 1999-04-29 WO disclosed