Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | CISD1 | Q9NZ45 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | NAT1 | P18440 | 1/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197957 | 1.00 | ALDH1A1 (0.60) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL20714251 | 0.82 | ALDH1A1 (0.80) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3893472 | 0.81 | ALDH1A1 (0.66) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL8190455 | 0.81 | MAPT (0.66) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL8191326 | 0.81 | MAPT (0.66) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3893467 | 0.81 | ALDH1A1 (0.66) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL8190456 | 0.81 | MAPT (0.66) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3122838 | 0.75 | POLB (1.00) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3122832 | 0.75 | POLB (1.00) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3122845 | 0.75 | POLB (1.00) | ALDH1A1LMNAPOLBMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000032598-A9 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC (US) | 2000-11-30 | — | — | WO | claimed |