Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.59 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | EP300 | Q09472 | 1/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.56 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122838 | 1.00 | POLB (1.00) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL3122845 | 1.00 | POLB (1.00) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL20714251 | 0.89 | ALDH1A1 (0.80) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL3897031 | 0.88 | POLB (0.78) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL3897032 | 0.88 | POLB (0.78) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL7858419 | 0.88 | POLB (0.78) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL3905838 | 0.88 | POLB (0.78) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL3905836 | 0.88 | POLB (0.78) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL3890737 | 0.87 | ALDH1A1 (0.77) | POLBALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL15317957 | 0.87 | MAPT (0.77) | POLBALDH1A1LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120219613-A1 | Novel Antiviral Agents for Enveloped Viruses | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-30 | — | — | US | claimed |
| WO-2010044924-A1 | NOVEL ANTIVIRAL AGENTS FOR ENVELOPED VIRUSES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-22 | — | — | WO | claimed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | claimed |
| WO-2005041951-A2 | RHODANINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | claimed |
| US-8933075-B2 | Compounds useful as antiviral agents, compositions, and methods of use | FUZIANS BIOMEDICALS, INC. (KY) | 2015-01-13 | — | — | US | disclosed |
| US-20130090339-A1 | COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE | THE UAB RESEARCH FOUNDATION (US) | 2013-04-11 | — | — | US | disclosed |
| US-20120219613-A1 | Novel Antiviral Agents for Enveloped Viruses | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2010044924-A1 | NOVEL ANTIVIRAL AGENTS FOR ENVELOPED VIRUSES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-22 | — | — | WO | disclosed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120219613-A1 | Novel Antiviral Agents for Enveloped Viruses | MAVS, LAMP1, HAVCR2 | POLB 4238/4885ALDH1A1 1264/4885LMNA 1519/4885 |
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | UBQLN1, UBQLN2, UBE2G2 | POLB 2008/4885ALDH1A1 1828/4885LMNA 3753/4885 |
| US-20130090339-A1 | COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE | SAMHD1, ZC3HAV1, DDX5 | POLB 84/4885ALDH1A1 3597/4885LMNA 3961/4885 |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RBX1, ITCH, UBQLN1 | POLB 433/4885ALDH1A1 3199/4885LMNA 4343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.