Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190950 | 0.96 | HTT (0.56) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL8189834 | 0.92 | LMNA (0.63) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL24486768 | 0.87 | HTT (0.63) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL9416993 | 0.85 | CETP (0.59) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL3397940 | 0.82 | HTT (0.60) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL3362572 | 0.81 | HTT (0.67) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL24486765 | 0.80 | HTT (0.65) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL22166825 | 0.80 | HTT (0.68) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL18254066 | 0.79 | HTT (0.81) | HTTLMNASMN1; SMN2L3MBTL1TGM2 | |
| SCHEMBL8851936 | 0.79 | CAPN1 (0.52) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934325-A4 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | PHARMASSET LTD (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-0934325-A1 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | Pharmasset, Ltd. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015563-A1 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | PHARMASSET, LTD. (US) | 1998-04-16 | — | — | WO | disclosed |