SCHEMBL8198017

SCHEMBL8198017

CCN(CC)c1ccc(C=NN(c2ccccc2)c2ccccc2)c(OCc2ccccc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.62
HTT P42858 5/20 0.62
GAA P10253 3/20 0.62
MAPK1 P28482 3/20 0.62
BACE1 P56817 1/20 0.53
ALDH1A1 P00352 5/20 0.43
KDM4E B2RXH2 5/20 0.43
L3MBTL1 Q9Y468 1/20 0.41
HPGD P15428 3/20 0.40
NOX1 Q9Y5S8 1/20 0.40
ALOX12 P18054 1/20 0.40
CA12 O43570 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
POLB P06746 2/20 0.40
EIF4H Q15056 1/20 0.40
LMNA P02545 5/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
MEN1 O00255 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8198016 1.00 MAPT (0.62) MAPTHTTGAAMAPK1BACE1
SCHEMBL1702511 0.89 MAPT (0.67) MAPTHTTGAAMAPK1BACE1
SCHEMBL1702513 0.89 MAPT (0.67) MAPTHTTGAAMAPK1BACE1
SCHEMBL8181026 0.85 MAPT (0.68) MAPTHTTGAAMAPK1ALDH1A1
SCHEMBL8181030 0.85 MAPT (0.68) MAPTHTTGAAMAPK1ALDH1A1
SCHEMBL14064764 0.82 MAPT (0.58) MAPTHTTGAAMAPK1BACE1
SCHEMBL3200550 0.81 ALDH1A1 (0.63) MAPTHTTBACE1ALDH1A1KDM4E
SCHEMBL18155193 0.81 BACE1 (0.58) MAPTHTTGAAMAPK1BACE1
SCHEMBL4819770 0.81 MAPT (0.57) MAPTHTTGAAMAPK1BACE1
SCHEMBL4819759 0.81 MAPT (0.57) MAPTHTTGAAMAPK1BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0462406-B1 An electrophotographic photosensitive material NEC CORP (JP) 1994-04-20 EP claimed
US-5061584-A Photosensitive layer contains butadiene, hydrazone and mono-phenol compounds; does not crack when oil drops or fingprints adhere to it SHINDENGEN ELECTRIC MANUFACTURING CO., LTD (JP) 1991-10-29 US claimed
US-4839252-A PHOTOSENSITIVE LAYER OF A BUTADIENE COMPOUND AND HYDRAZONE COMPOUND; SUPRESSING PHOTO DEGRADATION SHINDENGEN ELECTRIC MANUFACTURING CO., LTD (JP) 1989-06-13 US claimed
US-6156466-A Photoconductor for electrophotography FUJI ELECTRIC CO., LTD. (JP) 2000-12-05 US disclosed
US-4839252-A PHOTOSENSITIVE LAYER OF A BUTADIENE COMPOUND AND HYDRAZONE COMPOUND; SUPRESSING PHOTO DEGRADATION SHINDENGEN ELECTRIC MANUFACTURING CO., LTD (JP) 1989-06-13 US disclosed