Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945528 | 0.80 | BRD4 (0.60) | BRD4ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL21830986 | 0.78 | BRD4 (0.79) | BRD4ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL29922633 | 0.78 | BRD4 (0.79) | BRD4ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL15012132 | 0.77 | NPC1 (0.58) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2335910 | 0.77 | EPHX1 (0.76) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL30910867 | 0.76 | BRD4 (0.86) | BRD4ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2871030 | 0.76 | SMN1; SMN2 (0.57) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL31556680 | 0.76 | MAPT (0.54) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14096379 | 0.76 | ALDH1A1 (0.78) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11703206 | 0.74 | EPHX1 (0.58) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071524-A1 | 2-NH-PYRIDONES AND PYRIMIDONES AS MRS INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-30 | — | — | WO | disclosed |