Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752519 | 0.89 | GRM1 (0.59) | GRM1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL10090785 | 0.86 | GRM1 (0.53) | GRM1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL11201376 | 0.82 | NPSR1 (0.43) | GRM1 | |
| SCHEMBL4107701 | 0.80 | CYP1A2 (0.52) | GRM1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12529489 | 0.79 | GRM1 (0.53) | GRM1ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL11649335 | 0.79 | CYP1A2 (0.50) | GRM1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL10046850 | 0.79 | RAB9A (0.48) | GRM1ALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL10090840 | 0.79 | GRM1 (0.47) | GRM1CYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL3138229 | 0.78 | GRM1 (0.49) | GRM1ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL21060985 | 0.77 | LMNA (0.58) | GRM1ALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133305-A | PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED DISORDERS SUCH AS CANCER | SUGEN, INC. (US) | 2000-10-17 | — | — | US | disclosed |