Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.67 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | TERT | O14746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187984 | 0.91 | PTGS1 (0.76) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL8188115 | 0.80 | PTGS2 (0.70) | PTGS2PTGS1TERT | |
| SCHEMBL23052498 | 0.75 | MAOA (0.66) | PSMD14MAOAMAPTMEN1HTT | |
| SCHEMBL5693406 | 0.74 | PTGS2 (0.76) | PTGS2PTGS1MAPTMEN1HTT | |
| SCHEMBL5693352 | 0.73 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL5693256 | 0.73 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL5856418 | 0.72 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL4020011 | 0.72 | PTGS2 (0.76) | PTGS2PTGS1MAPT | |
| SCHEMBL5693232 | 0.72 | PTGS2 (0.76) | PTGS2PTGS1MAPT | |
| SCHEMBL3313161 | 0.71 | MAOA (0.84) | PSMD14MAOAMAPTMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000076983-A1 | 1-(4-ARYLSULFONYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | claimed |
| WO-2000076983-A1 | 1-(4-ARYLSULFONYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | disclosed |