Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.32 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.32 |
| ▸ | SGK1 | O00141 | 1/20 | 0.32 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271519 | 0.92 | SLC6A4 (0.37) | GAAHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8207539 | 0.90 | PTGDR2 (0.35) | GAAHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8205442 | 0.90 | AXL (0.39) | GAAHTTKDM4EALDH1A1AXL | |
| SCHEMBL8205766 | 0.84 | GAA (0.38) | GAAHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8205725 | 0.82 | EIF4E (0.33) | GAASMN1; SMN2RBBP9CTSA | |
| SCHEMBL8206760 | 0.82 | KDM4E (0.38) | GAAHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8212069 | 0.82 | FNTA (0.38) | — | |
| SCHEMBL8210020 | 0.81 | KDM4E (0.32) | GAAHTTKDM4EALDH1A1 | |
| SCHEMBL8199405 | 0.80 | NTRK1 (0.36) | GAAHTTKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL7241553 | 0.79 | KDM4E (0.43) | HTTKDM4ESMN1; SMN2SNCAGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |