Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14234938 | 0.88 | KDM4E (0.44) | KDM4ERAB9AHSD17B10MEN1USP2 | |
| SCHEMBL3925184 | 0.86 | KDM4E (0.50) | KDM4ERAB9AHSD17B10MEN1USP2 | |
| SCHEMBL5745707 | 0.84 | RAB9A (0.53) | KDM4ERAB9AHSD17B10MEN1USP2 | |
| SCHEMBL5749113 | 0.84 | RAB9A (0.53) | KDM4ERAB9AHSD17B10MEN1USP2 | |
| SCHEMBL1314885 | 0.84 | RAB9A (0.53) | KDM4ERAB9AHSD17B10MEN1USP2 | |
| SCHEMBL747715 | 0.82 | — | — | |
| SCHEMBL7210408 | 0.82 | HRH1 (0.50) | KDM4EMEN1KMT2ATSHRCA12 | |
| SCHEMBL13242764 | 0.78 | ADRA2A (0.39) | KDM4ERAB9AHSD17B10MEN1USP2 | |
| SCHEMBL19566680 | 0.78 | CHRNA7 (0.38) | NOS2NOS3NOS1CA12CA1 | |
| SCHEMBL14658656 | 0.76 | CA12 (0.44) | RAB9AMEN1ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738961-B1 | HETEROCYCLIC COMPOUND AS CSF-1R INHIBITOR AND USE THEREOF | MEDSHINE DISCOVERY INC (CN) | 2022-08-31 | — | — | EP | disclosed |
| EP-3302572-B1 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS INC (US) | 2021-01-06 | — | — | EP | disclosed |
| WO-2014089913-A1 | BICYCLIC COMPOUND FUNCTIONING AS TYROSINE KINASE INHIBITOR | 山东亨利医药科技有限责任公司 (CN) | 2014-06-19 | — | — | WO | disclosed |
| US-6080754-A | Pyrrolo[2,1,5-cd]indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes | NOVO NORDISK A/S (DK) | 2000-06-27 | — | — | US | disclosed |
| EP-0988303-A1 | PYRROLO 2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998055483-A9 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK AS (DK) | 2000-02-03 | — | — | WO | disclosed |
| WO-1998055483-A1 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | disclosed |