Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2C | Q14957 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236839 | 0.89 | GHSR (0.44) | GRIN2CGHSR | |
| SCHEMBL5899111 | 0.89 | CYP3A4 (0.48) | GRIN2CLMNAGHSR | |
| SCHEMBL17821736 | 0.78 | MTNR1B (0.55) | GRIN2CLMNATP53 | |
| SCHEMBL8199954 | 0.77 | GHSR (0.48) | LMNAGHSR | |
| SCHEMBL5899110 | 0.77 | CYP3A4 (0.51) | LMNAGHSR | |
| SCHEMBL8200141 | 0.77 | CYP3A4 (0.51) | LMNAGHSR | |
| SCHEMBL12394508 | 0.76 | MTNR1B (0.52) | LMNATP53GHSR | |
| SCHEMBL8243627 | 0.76 | GHSR (0.49) | GRIN2CLMNAGHSR | |
| SCHEMBL5899098 | 0.75 | GHSR (0.47) | LMNAGHSR | |
| SCHEMBL3074432 | 0.75 | GHSR (0.58) | GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043253-A | TREATMENT OF DIABETES, OBESITY, LOWERING TRIGLYCERIDE OR CHOLESTEROL LEVELS, INCREASING HIGH DENSITY LIPOPROTEIN LEVELS OR DECREASING GUT MOTILITY, REDUCING NEUROGENIC INFLAMMATION, DEPRESSION OR GASTROINTESTINAL DISORDERS | MERCK & CO., INC. (US) | 2000-03-28 | — | — | US | disclosed |