Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193845 | 0.88 | PDE3A (0.56) | PDE3APDE5ALMNAIGF1RMAPK14 | |
| SCHEMBL5810385 | 0.87 | PDE3A (0.65) | PDE3APDE5AIGF1RMAPK14MAPK1 | |
| SCHEMBL7367727 | 0.85 | LMNA (0.53) | PDE3APDE5ALMNAMAPK1CCNE2 | |
| SCHEMBL6818685 | 0.83 | PDE3A (0.47) | PDE3APDE5ALMNAIGF1RMAPK14 | |
| SCHEMBL8186528 | 0.82 | PDE3A (0.60) | PDE3APDE5ALMNAIGF1RMAPK14 | |
| SCHEMBL8193833 | 0.81 | ADORA1 (0.52) | IGF1RMAPK14MAPK1ADORA1ADORA3 | |
| SCHEMBL6824619 | 0.80 | LMNA (0.46) | PDE3APDE5ALMNAMAPK14MAPK1 | |
| SCHEMBL8185746 | 0.78 | PDE3A (0.57) | PDE3APDE5AIGF1RMAPK14MAPK1 | |
| SCHEMBL8195253 | 0.78 | PDE3A (0.57) | PDE3APDE5AIGF1RMAPK14MAPK1 | |
| SCHEMBL7664915 | 0.77 | ADORA1 (0.53) | LMNAIGF1RMAPK14MAPK1MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000024742-A1 | PYRAZOLOPYRIDINE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-04 | — | — | WO | disclosed |