Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395677 | 0.86 | PDE3A (0.42) | LMNAPDE3APDE5APDE3BPDE4B | |
| SCHEMBL7369957 | 0.85 | PDE3A (0.48) | LMNAPDE3APDE5APDE3BPDE4B | |
| SCHEMBL8199836 | 0.85 | PDE3A (0.60) | LMNACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7399130 | 0.81 | PDE3A (0.45) | LMNAPDE3APDE5APDE3BPDE4B | |
| SCHEMBL7366330 | 0.81 | PDE3A (0.40) | LMNAPDE3APDE5APDE3BPDE4B | |
| SCHEMBL7367166 | 0.79 | BRD4 (0.44) | LMNABRD4CCNE2CDK4CCND1 | |
| SCHEMBL6824619 | 0.78 | LMNA (0.46) | LMNAPDE3APDE5APDE3BPDE4B | |
| SCHEMBL7401220 | 0.78 | PDE3A (0.41) | PDE3APDE5APDE3BGSK3BDYRK1A | |
| SCHEMBL6818685 | 0.77 | PDE3A (0.47) | LMNAPDE3APDE5APDE4BPDE4A | |
| SCHEMBL7363841 | 0.75 | PDE3A (0.45) | PDE3APDE5APDE3BPDE4BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |