Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 9/20 | 0.61 |
| ▸ | MTTP | P55157 | 8/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213429 | 0.92 | APOB (0.55) | APOBMTTPSMOKDM4EALDH1A1 | |
| SCHEMBL8206946 | 0.92 | APOB (0.54) | APOBMTTPSMOKDM4EALDH1A1 | |
| SCHEMBL691418 | 0.92 | MTTP (0.59) | APOBMTTPSMOKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8408661 | 0.91 | MTTP (0.59) | APOBMTTPSMOKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3887925 | 0.91 | MTTP (0.59) | APOBMTTPSMOKDM4EALDH1A1 | |
| SCHEMBL8207484 | 0.90 | MTTP (0.53) | APOBMTTPSMOKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8410108 | 0.90 | MTTP (0.58) | APOBMTTPSMOKDM4EALDH1A1 | |
| SCHEMBL8208061 | 0.90 | MTTP (0.53) | APOBMTTPSMOKDM4EALDH1A1 | |
| SCHEMBL8200807 | 0.90 | MTTP (0.53) | APOBMTTPSMOKDM4EALDH1A1 | |
| SCHEMBL692958 | 0.90 | APOB (0.60) | APOBMTTPSMOKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121283-A | Apo B-secretion/MTP inhibitory amides | PFIZER INC (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0944602-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023593-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1998-06-04 | — | — | WO | disclosed |