Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.46 |
| ▸ | MTTP | P55157 | 12/20 | 0.59 |
| ▸ | APOB | P04114 | 9/20 | 0.59 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8408661 | 1.00 | MTTP (0.59) | MTTPAPOBSMOKDM4EGAA | |
| Hydrochloric Acid SCHEMBL8410108 | 0.99 | MTTP (0.58) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL691418 | 0.99 | MTTP (0.59) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8213429 | 0.92 | APOB (0.55) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8207484 | 0.91 | MTTP (0.53) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL692958 | 0.91 | APOB (0.60) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8208061 | 0.91 | MTTP (0.53) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8200807 | 0.91 | MTTP (0.53) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8199883 | 0.91 | APOB (0.61) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8206946 | 0.91 | APOB (0.54) | MTTPAPOBSMOKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968950-A | Apo B-secretion/MTP inhibitor hydrochloride salt | PFIZER INC (US) | 1999-10-19 | — | — | US | claimed |
| EP-0887345-A1 | 4'-trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-acetylaminoethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amide hydrochloride as apo B-secretion/MTP inhibitors | PFIZER INC. (US) | 1998-12-30 | — | — | EP | claimed |
| JP-11060557-A | — | — | None | — | — | JP | disclosed |
| US-7538124-B2 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-26 | — | — | US | disclosed |
| US-20080275087-A1 | BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | MEERPOEL LIEVEN | 2008-11-06 | — | — | US | disclosed |
| US-7405307-B2 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-29 | — | — | US | disclosed |
| US-20080009522-A1 | BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | MEERPOEL LIEVEN | 2008-01-10 | — | — | US | disclosed |
| US-7304167-B2 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-04 | — | — | US | disclosed |
| US-7244848-B2 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-17 | — | — | US | disclosed |
| US-7135586-B2 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA, NV (BE) | 2006-11-14 | — | — | US | disclosed |
| EP-1339685-B1 | BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2006-11-02 | — | — | EP | disclosed |
| US-20060128973-A1 | Biphenylcarboxamides useful as lipid lowering agents | MEERPOEL LIEVEN | 2006-06-15 | — | — | US | disclosed |
| US-20060128972-A1 | Biphenylcarboxamides useful as lipid lowering agents | MEERPOEL LIEVEN | 2006-06-15 | — | — | US | disclosed |
| US-20040102490-A1 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-05-27 | — | — | US | disclosed |
| US-5968950-A | Apo B-secretion/MTP inhibitor hydrochloride salt | PFIZER INC (US) | 1999-10-19 | — | — | US | disclosed |
| JP-H1160557-A | HYDROCHLORIDE OF APO B SECRETION/MTP INHIBITOR | PFIZER INC | 1999-03-02 | — | — | JP | disclosed |
| EP-0887345-A1 | 4'-trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-acetylaminoethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amide hydrochloride as apo B-secretion/MTP inhibitors | PFIZER INC. (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0887345-A1 | 4'-trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-acetylaminoethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amide hydrochloride as apo B-secretion/MTP inhibitors | PFIZER INC. (US) | 1998-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009522-A1 | BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | LIPC, PNLIP, FABP4 | GAA 531/4885MTTP 22/4885APOB 13/4885 |
| US-20080275087-A1 | BIPHENYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | LIPC, PNLIP, FABP4 | GAA 531/4885MTTP 22/4885APOB 13/4885 |
| US-20060128972-A1 | Biphenylcarboxamides useful as lipid lowering agents | LIPC, PNLIP, FABP4 | GAA 531/4885MTTP 22/4885APOB 13/4885 |
| US-20060128973-A1 | Biphenylcarboxamides useful as lipid lowering agents | LIPC, PNLIP, FABP4 | GAA 531/4885MTTP 22/4885APOB 13/4885 |
| US-20040102490-A1 | Biphenylcarboxamides useful as lipid lowering agents | LIPC, PNLIP, FABP4 | GAA 732/4885MTTP 37/4885APOB 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.