Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212665 | 0.93 | PDE5A (0.72) | PDE5A | |
| SCHEMBL7403451 | 0.92 | PDE5A (0.75) | PDE5A | |
| SCHEMBL8198747 | 0.89 | PDE5A (0.53) | PDE5AALDH1A1SMN1; SMN2RCE1RAB9A | |
| SCHEMBL7415070 | 0.88 | PDE5A (0.71) | PDE5A | |
| SCHEMBL8207075 | 0.86 | PDE5A (0.78) | PDE5A | |
| SCHEMBL7372006 | 0.85 | PDE5A (0.51) | PDE5ARAB9A | |
| SCHEMBL8210494 | 0.85 | PDE5A (0.49) | PDE5AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL8206824 | 0.84 | PDE5A (0.78) | PDE5A | |
| SCHEMBL7407315 | 0.83 | PDE5A (0.83) | PDE5A | |
| SCHEMBL7409432 | 0.82 | PDE5A (0.85) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | claimed |
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |