Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.48 |
| ▸ | PDE6A | P16499 | 1/20 | 0.48 |
| ▸ | PDE6G | P18545 | 1/20 | 0.48 |
| ▸ | PDE6B | P35913 | 1/20 | 0.48 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210494 | 0.93 | PDE5A (0.49) | PDE5AALDH1A1SMN1; SMN2RAB9APDE6D | |
| SCHEMBL8206815 | 0.92 | PDE5A (0.58) | PDE5APDE6C | |
| SCHEMBL8199929 | 0.89 | PDE5A (0.69) | PDE5AALDH1A1SMN1; SMN2RAB9ARCE1 | |
| SCHEMBL7372006 | 0.88 | PDE5A (0.51) | PDE5ARAB9A | |
| SCHEMBL8211624 | 0.84 | PDE5A (0.53) | PDE5A | |
| SCHEMBL8212665 | 0.81 | PDE5A (0.72) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7368497 | 0.81 | PDE5A (0.77) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7372999 | 0.81 | PDE5A (0.69) | PDE5APDE6C | |
| SCHEMBL7403451 | 0.81 | PDE5A (0.75) | PDE5A | |
| SCHEMBL8207695 | 0.80 | VCAM1 (0.59) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |