Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207695 | 0.93 | VCAM1 (0.59) | PDE5AVCAM1 | |
| SCHEMBL8210494 | 0.92 | PDE5A (0.49) | PDE5ARAB9A | |
| SCHEMBL8198747 | 0.88 | PDE5A (0.53) | PDE5ARAB9A | |
| SCHEMBL8211624 | 0.86 | PDE5A (0.53) | PDE5AVCAM1 | |
| SCHEMBL8199929 | 0.85 | PDE5A (0.69) | PDE5ARAB9A | |
| SCHEMBL8207666 | 0.84 | PDE5A (0.59) | PDE5A | |
| SCHEMBL7373885 | 0.84 | PDE5A (0.71) | PDE5A | |
| SCHEMBL7376362 | 0.83 | PDE5A (0.66) | PDE5A | |
| SCHEMBL8206815 | 0.81 | PDE5A (0.58) | PDE5A | |
| SCHEMBL7369832 | 0.80 | PDE5A (0.65) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085871-A4 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1085871-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| WO-1999064004-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |