Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204772 | 0.92 | HTR2C (0.50) | HTR2CACHEITGB3ITGA2BCCR5 | |
| SCHEMBL8192524 | 0.91 | HTR2C (0.47) | ALDH1A1HTR2CLMNAMAPTACHE | |
| SCHEMBL8201273 | 0.88 | HTR2C (0.48) | HTR2CLMNAMAPTACHEITGB3 | |
| SCHEMBL8199033 | 0.87 | HTR2C (0.46) | HTR2CACHEITGB3ITGA2B | |
| SCHEMBL8198493 | 0.86 | MAPT (0.47) | ALDH1A1HTR2CLMNAMAPTPOLB | |
| SCHEMBL8198779 | 0.85 | HTR2C (0.47) | HTR2CACHEITGB3ITGA2BCCR5 | |
| SCHEMBL8200675 | 0.83 | HTR2C (0.49) | ALDH1A1HTR2CMEN1KMT2A | |
| SCHEMBL8198980 | 0.82 | HTR2C (0.55) | HTR2C | |
| SCHEMBL8204780 | 0.82 | ACHE (0.44) | HTR2CACHEITGB3ITGA2BCCR5 | |
| SCHEMBL8204778 | 0.82 | ACHE (0.44) | HTR2CACHEITGB3ITGA2BCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |