Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT1A1 | P22309 | 3/20 | 0.83 |
| ▸ | MLNR | O43193 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.83 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.83 |
| ▸ | CCKAR | P32238 | 1/20 | 0.83 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.83 |
| ▸ | GHSR | Q92847 | 1/20 | 0.83 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.83 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.83 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705393 | 1.00 | UGT1A1 (0.83) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL8231384 | 1.00 | UGT1A1 (0.83) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL10204009 | 1.00 | UGT1A1 (0.83) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL8228540 | 1.00 | UGT1A1 (0.83) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL14240041 | 1.00 | UGT1A1 (0.83) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL8223501 | 1.00 | UGT1A1 (0.83) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL7822599 | 1.00 | UGT1A1 (0.83) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL8228992 | 0.94 | UGT1A1 (0.73) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL7820596 | 0.93 | UGT1A1 (0.72) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 | |
| SCHEMBL14479844 | 0.93 | UGT1A1 (0.72) | UGT1A1MLNRNR1I2SLCO2B1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170792-A1 | ATAZANAVIR METABOLITE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |
| US-20120108529-A1 | PROTEASE INHIBITORS | AMPLYX PHARMACEUTICALS, INC. | 2012-05-03 | — | — | US | disclosed |
| EP-2322509-A1 | Azapeptide derivatives as HIV protease inhibitors | Concert Pharmaceuticals Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2008065490-A2 | PROCESS FOR THE PREPARATION OF ATAZANAVIR | FIDIA FARMACEUTICI S.P.A. (IT) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108529-A1 | PROTEASE INHIBITORS | SERPINB1, PREP, DNPEP | UGT1A1 3949/4885MLNR 3925/4885NR1I2 4344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.