Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13343865 | 0.84 | BRD4 (0.57) | PARP1TSHRTP53LMNAMAOA | |
| SCHEMBL4933671 | 0.81 | MMP13 (0.58) | PARP1MMP12MMP8MMP13 | |
| SCHEMBL4934583 | 0.81 | PARP1 (0.53) | PARP1KMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL304764 | 0.79 | MAPT (0.62) | PARP1LMNAKMT2AMAPTALDH1A1 | |
| SCHEMBL14073051 | 0.78 | PARP1 (0.70) | PARP1TSHRTP53LMNAMAOA | |
| SCHEMBL27663635 | 0.78 | PARP1 (0.45) | PARP1TSHRTP53LMNAMAOA | |
| SCHEMBL14073116 | 0.77 | PARP1 (0.62) | PARP1TSHRTP53LMNAMAOA | |
| SCHEMBL4259329 | 0.77 | PARP1 (0.65) | PARP1KMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL531798 | 0.77 | TSHR (0.74) | PARP1TSHRTP53LMNAMAOA | |
| SCHEMBL4267366 | 0.76 | MMP12 (0.70) | PARP1KMT2AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |