Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13555429 | 0.90 | MAPT (0.49) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL8701323 | 0.88 | MAPT (0.48) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL21280378 | 0.87 | KCNH2 (0.49) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL19122581 | 0.87 | KCNH2 (0.49) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL5380629 | 0.85 | CYP1A2 (0.47) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL28062194 | 0.82 | POLB (0.46) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL14658480 | 0.82 | TSHR (0.55) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL1929601 | 0.82 | ADRA2A (0.46) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL13020594 | 0.81 | CYP2C19 (0.47) | POLBCYP1A2GAAPKMMAPT | |
| SCHEMBL18399532 | 0.81 | POLB (0.46) | POLBCYP1A2GAAPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9804168-B2 | Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics | OPKO PHARMACEUTICALS, LLC (US) | 2017-10-31 | — | — | US | disclosed |
| EP-2688911-B1 | Biomarker discovery in complex biological fluid using bead or particle based libraries | OPKO PHARMACEUTICALS LLC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-9551721-B2 | Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-01-24 | — | — | US | disclosed |
| US-6080754-A | Pyrrolo[2,1,5-cd]indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes | NOVO NORDISK A/S (DK) | 2000-06-27 | — | — | US | disclosed |
| EP-0988303-A1 | PYRROLO 2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998055483-A9 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK AS (DK) | 2000-02-03 | — | — | WO | disclosed |
| WO-1998055483-A1 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | disclosed |