Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992041 | 0.88 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL31456058 | 0.85 | LOXL2 (0.52) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL28062194 | 0.82 | POLB (0.46) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL14658480 | 0.82 | TSHR (0.55) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL8200767 | 0.82 | POLB (0.49) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL22557298 | 0.80 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL13555429 | 0.79 | MAPT (0.49) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL12526403 | 0.79 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL29966397 | 0.79 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CPOLBPKM | |
| SCHEMBL9657467 | 0.78 | FFAR1 (0.50) | ADRA2AADRA2BADRA2CPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | claimed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | claimed |
| US-8506945-B2 | Polymers with structure-defined functions | SMITH & NEPHEW, PLC. (GB) | 2013-08-13 | — | — | US | disclosed |
| US-20110300096-A1 | Polymers With Structure-Defined Functions | GREENER BRYAN (GB) | 2011-12-08 | — | — | US | disclosed |
| US-7955594-B2 | Maleic anhydride-methyl vinyl ether copolymers; polyamic acids; medical implant device, dressing, scaffold, or fluid adhesive for treatment or prophylaxis of wounds; enhanced activity of protease inhibitors and neurotransmitter drugs | SMITH & NEPHEW, PLC (GB) | 2011-06-07 | — | — | US | disclosed |
| US-20050032929-A1 | Polymers with structure-defined functions | SMITH & NEPHEW, PLC (GB) | 2005-02-10 | — | — | US | disclosed |
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1436334-A1 | POLYMERS WITH STRUCTURE-DEFINED FUNCTIONS | Smith & Nephew PLC (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003027154-A1 | POLYMERS WITH STRUCTURE-DEFINED FUNCTIONS | SMITH & NEPHEW PLC (GB) | 2003-04-03 | — | — | WO | disclosed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| US-5460754-A | Non-linear optical material, method of manufacturing the same and optical wavelength converter | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5346653-A | Non-linear optical material, method of manufacturing the same and optical wavelength converter | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1994-09-13 | — | — | US | disclosed |
| EP-0500050-A2 | Non-linear optical materials, method of manufacturing the same and optical wave length converter | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1992-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110300096-A1 | Polymers With Structure-Defined Functions | MMP1, MMP8, ADAM12 | ADRA2A 1909/4885ADRA2B 2569/4885ADRA2C 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.