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Sugi Predict / Compounds / Arginine

Arginine

Arginine

SCHEMBL8200772

CC[C@H](C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CS)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MAPK8 P45983 1/20 0.34
▸ MAPK9 P45984 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ NFE2L2 Q16236 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL6375974 0.99 MAPK8 (0.33) MAPK8MAPK9MAPK10NFE2L2
Arginine SCHEMBL8203742 0.96 MAPK8 (0.32) MAPK8MAPK9MAPK10NFE2L2
Arginine SCHEMBL2501111 0.87 PRCP (0.36) MAPK8MAPK9MAPK10
Arginine SCHEMBL17982370 0.87 PRCP (0.36) MAPK8MAPK9MAPK10
Arginine SCHEMBL9164072 0.86 KDM1A (0.35) MAPK8MAPK9MAPK10
Arginine SCHEMBL28818309 0.86 GSR (0.37) —
Arginine SCHEMBL28199097 0.86 REN (0.39) MAPK8MAPK9MAPK10
Arginine SCHEMBL28022079 0.86 REN (0.39) MAPK8MAPK9MAPK10
Arginine SCHEMBL28465970 0.85 PRCP (0.33) —
Arginine SCHEMBL4396599 0.85 PRCP (0.35) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015595-A1 PEPTIDES DERIVED FROM THE ATTACHMENT (G) PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS AMERICAN CYANAMID COMPANY (US) 2000-07-05 — — EP claimed
WO-1999014334-A1 PEPTIDES DERIVED FROM THE ATTACHMENT (G) PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS AMERICAN CYANAMID COMPANY (US) 1999-03-25 — — WO claimed