Known targets — ChEMBL curated mechanism
ATP1A1ATP1A2ATP1A3ATP1A4ATP1B1ATP1B2ATP1B3FXYD2
The experimentally established mechanism targets of Digoxin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP1A1 known ✓ | P05023 | 15/20 | 1.00 |
| ▸ | ATP1B1 known ✓ | P05026 | 15/20 | 1.00 |
| ▸ | ATP1B2 known ✓ | P14415 | 15/20 | 1.00 |
| ▸ | ATP1A2 known ✓ | P50993 | 15/20 | 1.00 |
| ▸ | ATP1B3 known ✓ | P54709 | 15/20 | 1.00 |
| ▸ | ATP1A3 known ✓ | P13637 | 3/20 | 1.00 |
| ▸ | FXYD2 known ✓ | P54710 | 3/20 | 1.00 |
| ▸ | ATP1A4 known ✓ | Q13733 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | STAT3 | P40763 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | RORC | P51449 | 1/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Digoxin SCHEMBL16341971 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL15959376 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13496260 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL20506 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13337586 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13354340 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL12841137 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL16144399 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL22904197 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13199062 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108165611-A | A kind of methods and applications of recombinase polymerase constant-temperature amplification combination ELISA test strip staphylococcus aureus | 天津科技大学 | 2018-06-15 | — | — | CN | claimed |
| CN-108148894-A | A kind of methods and applications of recombinase polymerase constant-temperature amplification combination ELISA test strip Listeria monocytogenes | 中科智测(天津)科技有限公司 | 2018-06-12 | — | — | CN | claimed |
| WO-2018141804-A1 | METHODS, ARRAYS AND USES THEREOF | IMMUNOVIA AB (SE) | 2018-08-09 | — | — | WO | disclosed |
| EP-3353552-A2 | METHOD, ARRAY AND USE THEREOF | Immunovia AB (SE) | 2018-08-01 | — | — | EP | disclosed |
| CN-108165611-A | A kind of methods and applications of recombinase polymerase constant-temperature amplification combination ELISA test strip staphylococcus aureus | 天津科技大学 | 2018-06-15 | — | — | CN | disclosed |
| CN-108148894-A | A kind of methods and applications of recombinase polymerase constant-temperature amplification combination ELISA test strip Listeria monocytogenes | 中科智测(天津)科技有限公司 | 2018-06-12 | — | — | CN | disclosed |
| EP-3152578-A2 | METHOD AND ARRAYS FOR USE IN DIAGNOSING EARLY BREAST CANCER | Immunovia AB (SE) | 2017-04-12 | — | — | EP | disclosed |
| WO-2017050939-A2 | METHOD, ARRAY AND USE THEREOF | IMMUNOVIA AB (SE) | 2017-03-30 | — | — | WO | disclosed |
| WO-2015189591-A2 | METHODS AND ARRAYS FOR USE IN THE SAME | IMMUNOVIA AB (SE) | 2015-12-17 | — | — | WO | disclosed |
| CN-103638036-B | Application of cardenolide compound in preparation of drugs treating sepsis immunoparalysis | NANJING UNIVERSITY OF TECHNOLOGY | 2015-03-04 | — | — | CN | disclosed |
| CN-103638036-A | Application of cardenolide compound in preparation of drugs treating sepsis immunoparalysis | NANJING UNIVERSITY OF TECHNOLOGY | 2014-03-19 | — | — | CN | disclosed |
| US-5741708-A | AUTOMATED IMMUNOASSAY TESTING | CHIRON DIAGNOSTICS CORPORATION (US) | 1998-04-21 | — | — | US | disclosed |
| US-5679948-A | Constant luminescence source module for an automated analyzer | CHIRON DIAGNOSTICS CORPORATION (US) | 1997-10-21 | — | — | US | disclosed |
| US-5653940-A | MEASURES INTENSITY OF CHEMILUMINESCENT FLASH INITIATED AS INDICATION OF PRESENCE OR ABSENCE OF ANALYTE IN TEST FLUID BEING ASSAYED | CHIRON DIAGNOSTICS CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5637275-A | Automated analyzer with reagent agitating device | CHIRON DIAGNOSTICS CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5582796-A | BIOLOGICAL APPARATUS | CIBA CORNING DIAGNOSTICS CORP. (US) | 1996-12-10 | — | — | US | disclosed |
| WO-1992014138-A1 | METHOD AND APPARATUS FOR MAGNETIC MICROPARTICULATE BASED LUMINESCENCE ASSAY INCLUDING PLURALITY OF MAGNETS | IGEN, INC. (US) | 1992-08-20 | — | — | WO | disclosed |
| US-4734378-A | SULFOSALICYCLIC ACID AND ALCOHOL | ABBOTT LABORATORIES (US) | 1988-03-29 | — | — | US | disclosed |
| US-4255411-A | DIGOXIN ASSAY | DAMON CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4071409-A | POLYMERIC ISOCYANATE COUPLER | CORNING GLASS WORKS (US) | 1978-01-31 | — | — | US | disclosed |