SCHEMBL8201404

SCHEMBL8201404

c1ccc(-c2cc(-c3ccc(C4=NCCN4)cc3)no2)nc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 5/20 0.56
MAOB P27338 7/20 0.50
CYP1A2 P05177 2/20 0.50
ALDH1A1 P00352 2/20 0.50
HPGD P15428 1/20 0.50
CASP1 P29466 1/20 0.50
CASP7 P55210 1/20 0.50
HSD17B10 Q99714 1/20 0.50
CXCR1 P25024 1/20 0.49
TOP2A P11388 2/20 0.48
TOP2B Q02880 2/20 0.48
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
MAOA P21397 5/20 0.46
NPC1 O15118 1/20 0.45
MAPT P10636 1/20 0.45
PKM P14618 1/20 0.45
RAB9A P51151 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8214278 0.85 ALDH1A1 (0.65) NISCHMAOBCYP1A2ALDH1A1HPGD
SCHEMBL1794747 0.85 TOP2A (0.61) NISCHMAOBCYP1A2ALDH1A1HPGD
Hydrochloric Acid SCHEMBL1795721 0.84 TOP2A (0.62) NISCHMAOBCYP1A2ALDH1A1HPGD
SCHEMBL2781659 0.83 NISCH (0.74) NISCHCYP1A2ALDH1A1HPGDCASP1
SCHEMBL1796041 0.82 NISCH (0.56) NISCHMAOBCYP1A2ALDH1A1HPGD
Hydrochloric Acid SCHEMBL1796884 0.81 NISCH (0.55) NISCHMAOBCYP1A2ALDH1A1HPGD
SCHEMBL1795198 0.79 NISCH (0.56) NISCHMAOBCYP1A2ALDH1A1HPGD
SCHEMBL8211455 0.79 NISCH (0.65) NISCHMAOBCYP1A2ALDH1A1HPGD
SCHEMBL8188588 0.79 LMNA (0.63) NISCHMAOBCYP1A2ALDH1A1HPGD
Hydrochloric Acid SCHEMBL8196753 0.78 TOP2A (0.55) NISCHMAOBCYP1A2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000078726-A1 IMIDAZOLINE DERIVATIVES FOR THE TREATMENT OF DIABETES, ESPECIALLY TYPE II DIABETES ELI LILLY AND COMPANY (US) 2000-12-28 WO disclosed