Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | RORC | P51449 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8220610 | 0.99 | DRD2 (0.46) | DRD2DRD3RORCMAPTSMN1; SMN2 | |
| SCHEMBL8221080 | 0.87 | MAPT (0.54) | MAPTSMN1; SMN2KDM4ENPC1LMNA | |
| Hydrochloric Acid SCHEMBL8218987 | 0.86 | MAPT (0.53) | MAPTSMN1; SMN2KDM4ENPC1LMNA | |
| SCHEMBL8201498 | 0.86 | MAPT (0.48) | MAPTSMN1; SMN2KDM4ENPC1LMNA | |
| Hydrochloric Acid SCHEMBL8221068 | 0.85 | MAPT (0.47) | MAPTSMN1; SMN2KDM4ENPC1LMNA | |
| SCHEMBL8218244 | 0.84 | MAPT (0.45) | RORCMAPTSMN1; SMN2KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL8222018 | 0.84 | MAPT (0.44) | RORCMAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL8221093 | 0.84 | MAPT (0.44) | DRD2DRD3MAPTSMN1; SMN2KDM4E | |
| SCHEMBL8209221 | 0.84 | MAOB (0.52) | MAPTSMN1; SMN2KDM4ENPC1LMNA | |
| SCHEMBL8201867 | 0.84 | MAPT (0.63) | MAPTSMN1; SMN2KDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | claimed |
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | disclosed |