Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12853603 | 0.93 | MEN1 (0.55) | MEN1KMT2AMAPTTSHRKDM4E | |
| SCHEMBL8208606 | 0.85 | MAPT (0.53) | MEN1KMT2AMAPTTSHRKDM4E | |
| SCHEMBL17012010 | 0.82 | KDM4E (0.58) | MEN1KMT2AMAPTKDM4EHSD17B10 | |
| SCHEMBL8208766 | 0.81 | KMT2A (0.50) | MEN1KMT2AMAPTKDM4EHSD17B10 | |
| SCHEMBL8208762 | 0.81 | KDM4E (0.57) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8201484 | 0.81 | KDM4E (0.57) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL12853206 | 0.78 | MAPT (0.54) | MEN1KMT2AMAPTTSHRKDM4E | |
| SCHEMBL12853598 | 0.74 | NOS2 (0.67) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL12855299 | 0.74 | KDM4E (0.60) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8212461 | 0.74 | KDM4E (0.60) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008082487-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |