Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201520 | 1.00 | HTR6 (0.84) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL8208531 | 0.91 | HTR6 (1.00) | HTR6 | |
| SCHEMBL8208527 | 0.91 | HTR6 (1.00) | HTR6 | |
| SCHEMBL8208038 | 0.88 | HTR6 (1.00) | HTR6 | |
| SCHEMBL8201574 | 0.88 | HTR6 (1.00) | HTR6 | |
| SCHEMBL8213978 | 0.86 | HTR6 (0.82) | HTR6 | |
| SCHEMBL8208595 | 0.86 | HTR6 (0.82) | HTR6 | |
| SCHEMBL8209793 | 0.85 | HTR6 (0.75) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL8209790 | 0.85 | HTR6 (0.75) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL8209383 | 0.80 | HTR6 (0.79) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |