Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200411 | 0.95 | LPAR1 (0.45) | LPAR1KDM4EALDH1A1POLBHPGD | |
| SCHEMBL8196542 | 0.93 | LPAR1 (0.42) | LPAR1NLRP3CXCL8MAPK1PYGL | |
| SCHEMBL8196624 | 0.91 | CXCL8 (0.38) | LPAR1NLRP3CXCL8MAPK1PYGL | |
| SCHEMBL8197446 | 0.87 | LPAR1 (0.41) | LPAR1NLRP3KMT2A | |
| SCHEMBL8197390 | 0.87 | LPAR1 (0.47) | LPAR1NLRP3KMT2A | |
| SCHEMBL8195984 | 0.86 | LPAR1 (0.45) | LPAR1NLRP3CXCL8MAPK1PYGL | |
| SCHEMBL8196843 | 0.86 | MEN1 (0.36) | LPAR1POLBNLRP3CXCL8MAPK1 | |
| SCHEMBL8189174 | 0.86 | MEN1 (0.36) | LPAR1POLBNLRP3CXCL8MAPK1 | |
| SCHEMBL8197433 | 0.86 | LPAR1 (0.40) | LPAR1NLRP3KMT2A | |
| SCHEMBL8196116 | 0.83 | S1PR2 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36832-E | AN ANTICHOLESTEROL AGENT TREATING HYPERCHOLESTEROLEMIA | NIHON NOHYAKU CO., LTD (JP) | 2000-08-22 | — | — | US | disclosed |
| EP-0613894-B1 | N-Heteroaryl-N'-phenylurea derivatives, their production and use | NIHON NOHYAKU CO LTD (JP) | 1999-05-06 | — | — | EP | disclosed |
| US-5464863-A | Anticholesterol agents | NIHON NOHYAKU CO., LTD. (JP) | 1995-11-07 | — | — | US | disclosed |
| EP-0613894-A1 | N-Heteroaryl-N'-phenylurea derivatives, their production and use | NIHON NOHYAKU CO., LTD. (JP) | 1994-09-07 | — | — | EP | disclosed |