Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | GYS1 | P13807 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196073 | 0.90 | ENPP1 (0.35) | MAPK14PTGS2ENPP1MAPK1NPSR1 | |
| SCHEMBL8642544 | 0.83 | — | — | |
| SCHEMBL8637992 | 0.81 | MAPK14 (0.46) | MAPK14PTGS2MAPK1NPSR1MAPK13 | |
| SCHEMBL8201927 | 0.81 | IKBKE (0.39) | PTGS2MAPK1RPS6KA3 | |
| SCHEMBL5078441 | 0.80 | PTGS2 (0.53) | MAPK14PTGS2MAPK11PTGS1 | |
| SCHEMBL6180483 | 0.80 | PTGS2 (0.53) | MAPK14PTGS2MAPK11PTGS1 | |
| SCHEMBL14519434 | 0.79 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4212020 | 0.79 | PTGS2 (0.52) | MAPK14PTGS2MAPK11PTGS1 | |
| SCHEMBL8194882 | 0.78 | PTGS2 (0.38) | PTGS2PTGS1 | |
| SCHEMBL8194744 | 0.76 | MAPK14 (0.41) | MAPK14PTGS2ENPP1GYS1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |