Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | ILK | Q13418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200029 | 0.82 | XDH (0.39) | MAPK14MAPK1NPSR1MAPK13MAPK12 | |
| SCHEMBL8201683 | 0.81 | MAPK14 (0.44) | MAPK14PTGS2MAPK1NPSR1MAPK13 | |
| SCHEMBL8194840 | 0.79 | MAPT (0.37) | MAPK14MAPK1NPSR1 | |
| SCHEMBL8639382 | 0.77 | MAPK14 (0.44) | MAPK14PTGS2TYMPMAPK13MAPK12 | |
| SCHEMBL8195999 | 0.75 | MAPK14 (0.43) | MAPK14PTGS2TYMPMAPK1MAPK13 | |
| SCHEMBL444633 | 0.71 | ACHE (0.41) | — | |
| SCHEMBL14467510 | 0.71 | ACHE (0.41) | — | |
| SCHEMBL8196073 | 0.70 | ENPP1 (0.35) | MAPK14PTGS2MAPK1NPSR1RPS6KA3 | |
| SCHEMBL8196926 | 0.69 | CA2 (0.42) | MAPK14PTGS2 | |
| SCHEMBL8201927 | 0.68 | IKBKE (0.39) | PTGS2MAPK1RPS6KA3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856000-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-05 | — | — | EP | disclosed |
| WO-1997013755-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-17 | — | — | WO | disclosed |